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Title: Perioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial.
Authors: Myles, PS 
Peyton, PJ 
Silbert, BS 
Hunt, J
Rigg, JR
Sessler, DI
ANZCA Clinical Trials Network 
Keywords: epidural analgesia
Issue Date: 29-Mar-2011
Source: 342:d1491
Abstract: Objective To compare long term recurrence of cancer and survival of patients having major abdominal surgery for cancer. Design Long term follow-up of prospective randomised controlled clinical trial in which patients were randomly assigned to receive general anaesthesia with or without epidural block for at least three postoperative days. Setting 23 hospitals in Australia, New Zealand, and Asia. Participants 503 adult patients who had potentially curative surgery for cancer. Main outcome measure Cancer-free survival (analysis was by intention to treat). Results Long term follow-up data were available for 94% (n=446) of eligible participants. The median time to recurrence of cancer or death was 2.8 (95% confidence interval 0.7 to 8.7) years in the control group and 2.6 (0.7 to 8.7) years in the epidural group (P=0.61). Recurrence-free survival was similar in both epidural and control groups (hazard ratio 0.95, 95% confidence interval 0.76 to 1.17; P=0.61). Conclusion Use of epidural block in abdominal surgery for cancer is not associated with improved cancer-free survival. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12607000637448
DOI: 10.1136/bmj.d1491.
PubMed URL:
Study Name: ACTRN12607000637448: Perioperative Epidural Analgesia and Incidence of Late Cancer Recurrence. A follow-up study of patients with cancer who were previously enrolled in the MASTER Trial
Journal Title: the BMJ
Type: Journal Article
Study/Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
Appears in Collections:Scholarly and Clinical

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