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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/608
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dc.contributor.authorMyles, PSen_US
dc.contributor.authorPeyton, PJen_US
dc.contributor.authorSilbert, BSen_US
dc.contributor.authorHunt, Jen_US
dc.contributor.authorRigg, JRen_US
dc.contributor.authorSessler, DIen_US
dc.contributor.authorANZCA Clinical Trials Networken_US
dc.date.accessioned2018-06-20T03:37:15Z-
dc.date.available2018-06-20T03:37:15Z-
dc.date.issued2011-03-29-
dc.identifier.citation342:d1491en_US
dc.identifier.urihttp://hdl.handle.net/11055/608-
dc.description.abstractObjective To compare long term recurrence of cancer and survival of patients having major abdominal surgery for cancer. Design Long term follow-up of prospective randomised controlled clinical trial in which patients were randomly assigned to receive general anaesthesia with or without epidural block for at least three postoperative days. Setting 23 hospitals in Australia, New Zealand, and Asia. Participants 503 adult patients who had potentially curative surgery for cancer. Main outcome measure Cancer-free survival (analysis was by intention to treat). Results Long term follow-up data were available for 94% (n=446) of eligible participants. The median time to recurrence of cancer or death was 2.8 (95% confidence interval 0.7 to 8.7) years in the control group and 2.6 (0.7 to 8.7) years in the epidural group (P=0.61). Recurrence-free survival was similar in both epidural and control groups (hazard ratio 0.95, 95% confidence interval 0.76 to 1.17; P=0.61). Conclusion Use of epidural block in abdominal surgery for cancer is not associated with improved cancer-free survival. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12607000637448en_US
dc.subjectepidural analgesiaen_US
dc.subjectMASTER TRIALen_US
dc.titlePerioperative epidural analgesia for major abdominal surgery for cancer and recurrence-free survival: randomised trial.en_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitlethe BMJen_US
dc.identifier.doi10.1136/bmj.d1491.en_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/21447587en_US
dc.type.studyortrialRandomized Controlled Clinical Trial/Controlled Clinical Trialen_US
dc.identifier.studynameACTRN12607000637448: Perioperative Epidural Analgesia and Incidence of Late Cancer Recurrence. A follow-up study of patients with cancer who were previously enrolled in the MASTER Trialen_US
dc.ispartof.anzcaresearchfoundationYesen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
Appears in Collections:Scholarly and Clinical
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