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Title: Novel immune biomarkers in complex regional pain syndrome
Authors: Russo M 
Georgius P
Staats Pires A
Heng B
Allwright M
Guennewig B
Santarelli DM
Bailey D
Fiore TN
Tan VX
Latini A
Guillemin GJ
Austin PJ
Keywords: complex regional pain syndrome
Issue Date: 15-Oct-2020
Source: Oct 15:347:577330.
Abstract: We investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with positive correlations between kynurenine/tryptophan ratio and TNF-α levels with kinesiophobia, tetrahydrobiopterin levels with McGill pain score, sRAGE, and xanthurenic acid and neopterin levels with depression, anxiety and stress scores. Using machine learning, we identified a set of binary variables, including IL-37 and GM-CSF, capable of distinguishing controls from established CRPS subjects. These results suggest possible involvement of various inflammatory markers in CRPS pathogenesis.
ISSN: 0165-5728
Appears in Collections:Scholarly and Clinical

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