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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/1214
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dc.contributor.authorRusso Men_US
dc.contributor.authorGeorgius Pen_US
dc.contributor.authorStaats Pires Aen_US
dc.contributor.authorHeng Ben_US
dc.contributor.authorAllwright Men_US
dc.contributor.authorGuennewig Ben_US
dc.contributor.authorSantarelli DMen_US
dc.contributor.authorBailey Den_US
dc.contributor.authorFiore TNen_US
dc.contributor.authorTan VXen_US
dc.contributor.authorLatini Aen_US
dc.contributor.authorGuillemin GJen_US
dc.contributor.authorAustin PJen_US
dc.date2020-07-21-
dc.date.accessioned2024-05-07T00:23:54Z-
dc.date.available2024-05-07T00:23:54Z-
dc.date.issued2020-10-15-
dc.identifier.citationOct 15:347:577330.en_US
dc.identifier.issn0165-5728en_US
dc.identifier.urihttps://hdl.handle.net/11055/1214-
dc.description.abstractWe investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with positive correlations between kynurenine/tryptophan ratio and TNF-α levels with kinesiophobia, tetrahydrobiopterin levels with McGill pain score, sRAGE, and xanthurenic acid and neopterin levels with depression, anxiety and stress scores. Using machine learning, we identified a set of binary variables, including IL-37 and GM-CSF, capable of distinguishing controls from established CRPS subjects. These results suggest possible involvement of various inflammatory markers in CRPS pathogenesis.en_US
dc.subjectcomplex regional pain syndromeen_US
dc.subjectcytokinesen_US
dc.subjectinflammationen_US
dc.subjectkynurenineen_US
dc.subjecttetrahydrobiopterinen_US
dc.subjecttryptophanen_US
dc.titleNovel immune biomarkers in complex regional pain syndromeen_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleJournal of Neuroimmunologyen_US
dc.identifier.doi10.1016/j.jneuroim.2020.577330en_US
dc.description.affiliatesHunter Pain Specialists, Broadmeadow, NSW, Australiaen_US
dc.description.affiliatesPain Rehab, Sunshin Coast, QLD, Australiaen_US
dc.description.affiliatesNeuroinflammation Group; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences; Macquarie University, Sydney, NSW, Australiaen_US
dc.description.affiliatesForeFront, Brain & Mind Centre, The University of Sydney, NSW, Australia.en_US
dc.description.affiliatesGenesis Research Services, Broadmeadow, NSW, Australiaen_US
dc.description.affiliatesDiscipline of Anatomy & Histology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.en_US
dc.description.affiliatesLaboratório de Bioenergética e Estresse Oxidativo, LABOX; Departamento de Bioquímica, CCB; Universidade Federal de Santa Catarina; Florianópolis / SC, Brazilen_US
dc.description.affiliatesDiscipline of Anatomy & Histology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, Australiaen_US
dc.description.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/32731051en_US
dc.type.studyortrialStudyen_US
dc.type.specialtyPain Medicineen_US
dc.identifier.fulltextlinkhttps://www.jni-journal.com/article/S0165-5728(20)30339-8/en_US
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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