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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/604
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dc.contributor.authorMyles, PSen_US
dc.contributor.authorLeslie, Ken_US
dc.contributor.authorMcNeil, Jen_US
dc.contributor.authorForbes, Aen_US
dc.contributor.authorChan, MTVen_US
dc.date.accessioned2018-06-20T03:35:11Z-
dc.date.available2018-06-20T03:35:11Z-
dc.date.issued2004-05-
dc.identifier.citation363(9423):1757-63.en_US
dc.identifier.urihttp://hdl.handle.net/11055/604-
dc.description.abstractBACKGROUND: Awareness is an uncommon complication of anaesthesia, affecting 0.1-0.2% of all surgical patients. Bispectral index (BIS) monitoring measures the depth of anaesthesia and facilitates anaesthetic titration. In this trial we determined whether BIS-guided anaesthesia reduced the incidence of awareness during surgery in adults. METHODS: We did a prospective, randomised, double-blind, multicentre trial. Adult patients at high risk of awareness were randomly allocated to BIS-guided anaesthesia or routine care. Patients were assessed by a blinded observer for awareness at 2-6 h, 24-36 h, and 30 days after surgery. An independent committee, blinded to group identity, assessed every report of awareness. The primary outcome measure was confirmed awareness under anaesthesia at any time. FINDINGS: Of 2463 eligible and consenting patients, 1225 were assigned to the BIS group and 1238 to the routine care group. There were two reports of awareness in the BIS-guided group and 11 reports in the routine care group (p=0.022). BIS-guided anaesthesia reduced the risk of awareness by 82% (95% CI 17-98%). INTERPRETATION: BIS-guided anaesthesia reduces the risk of awareness in at-risk adult surgical patients undergoing relaxant general anaesthesia. With a cost of routine BIS monitoring at US16 dollars per use in Australia and a number needed to treat of 138, the cost of preventing one case of awareness in high-risk patients is about 2200 dollars.en_US
dc.titleBispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial.en_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleLanceten_US
dc.description.affiliatesThe Alfred Hospitalen_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/15172773en_US
dc.type.studyortrialRandomized Controlled Clinical Trial/Controlled Clinical Trialen_US
dc.identifier.studynameB-Aware Trialen_US
dc.ispartof.anzcaresearchfoundationYesen_US
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
Appears in Collections:Scholarly and Clinical
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