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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/156
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dc.contributor.authorLe, Caroline P-
dc.contributor.authorNowell, Cameron J-
dc.contributor.authorKim-Fuchs, Corina-
dc.contributor.authorBotteri, Edoardo-
dc.contributor.authorHiller, JG-
dc.contributor.authorIsmail, H-
dc.contributor.authorPimentel, Matthew A-
dc.contributor.authorChai, Ming G-
dc.contributor.authorKarnezis, Tara-
dc.contributor.authorRotmensz, Nicole-
dc.contributor.authorRenne, Giuseppe-
dc.contributor.authorGandini, Sara-
dc.contributor.authorPouton, Colin W-
dc.contributor.authorFerrar, Davide-
dc.contributor.authorMöller, Andreas-
dc.contributor.authorStacker, Steven A-
dc.contributor.authorSloan, Erica K-
dc.date2016-
dc.date.accessioned2018-02-22T03:00:39Z-
dc.date.available2018-02-22T03:00:39Z-
dc.date.issued2016-03-01-
dc.identifier.citationNature communications 2016-03-01; 7: 10634-
dc.identifier.urihttp://hdl.handle.net/11055/156-
dc.description.abstractChronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination are unclear. Here we show that chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape. We show that VEGFC derived from tumour cells is required for stress to induce lymphatic remodelling and that this depends on COX2 inflammatory signalling from macrophages. Pharmacological inhibition of SNS signalling blocks the effect of chronic stress on lymphatic remodelling in vivo and reduces lymphatic metastasis in preclinical cancer models and in patients with breast cancer. These findings reveal unanticipated communication between stress-induced neural signalling and inflammation, which regulates tumour lymphatic architecture and lymphogenous tumour cell dissemination. These findings suggest that limiting the effects of SNS signalling to prevent tumour cell dissemination through lymphatic routes may provide a strategy to improve cancer outcomes.-
dc.language.isoeng-
dc.subject.meshAnimals-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Line-
dc.subject.meshChronic Disease-
dc.subject.meshCyclooxygenase 2-
dc.subject.meshFemale-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshLymphatic System-
dc.subject.meshMice-
dc.subject.meshMice, Inbred BALB C-
dc.subject.meshMice, Nude-
dc.subject.meshNeoplasms-
dc.subject.meshNeoplasms, Experimental-
dc.subject.meshSignal Transduction-
dc.subject.meshStress, Physiological-
dc.subject.meshVascular Endothelial Growth Factor C-
dc.titleChronic stress in mice remodels lymph vasculature to promote tumour cell dissemination.-
dc.typeJournal Article-
dc.typeResearch Support, N.I.H., Extramural-
dc.typeResearch Support, Non-U.S. Gov't-
dc.identifier.journaltitleNature communications-
dc.identifier.doi10.1038/ncomms10634-
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/26925549-
dc.identifier.pubmedid26925549-
dc.ispartof.anzcaresearchfoundationYes-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairetypeResearch Support, N.I.H., Extramural-
item.openairetypeResearch Support, Non-U.S. Gov't-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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