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dc.contributor.authorHolyoak, RSen_US
dc.contributor.authorMelhuish, TMen_US
dc.contributor.authorVlok, Ren_US
dc.contributor.authorBinks, Men_US
dc.contributor.authorWhite, LDen_US
dc.identifier.citation41:42-48. Epub 2017 Apr 30.en_US
dc.description.abstractPurpose: To determine whether or not apnoeic oxygenation reduces the incidence of hypoxaemia during endotracheal intubation. Materials and methods: A systematic search of six databases for all relevant studies until November 2016 was performed. All study designs using apnoeic oxygenation during intubation were eligible for inclusion. All studies were assessed for level of evidence and risk of bias. A meta-analysis was performed on all data using Revman 5.3. Results: Seventeen studies including 2422 patients were retrieved. Overall there was a significant reduction in the incidence of desaturation (RR=0.65; p<0.00001), critical desaturation (RR=0.61, p=0.002) and safe apnoea time (WMD=1.73min, p<0.00001). There was no significant difference in mortality (RR=0.77, p=0.08). Conclusions: In patients whom are being intubated for any indication other than respiratory failure, apnoeic oxygenation at any flow rate 15L or greater is likely to reduce their incidence of desaturation (<90%) and critical desaturation (<80%). However, further high quality RCTs are required given the high degree of heterogeneity in many of the outcomes and subgroup analyses.en_US
dc.subjectapnoeic oxygenationen_US
dc.titleIntubation using apnoeic oxygenation to prevent desaturation: A systematic review and meta-analysisen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of critical care.en_US
dc.description.affiliatesSchool of Medicine, University of Wollongong, NSW, Australia; Wagga Wagga Rural Referral Hospital, NSW, Australia.en_US
dc.type.studyortrialReviews/Systematic Reviewsen_US
dc.contributor.anzcaWhite, LDen_US
Appears in Collections:Scholarly and Clinical

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