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dc.contributor.authorYoung, Jen_US
dc.contributor.authorMacpherson, Aen_US
dc.contributor.authorThakerar, Aen_US
dc.contributor.authorAlexander, Men_US
dc.description.abstractBackground: Colorectal cancer surgery is commonly performed with adequate analgesia essential for patient recovery. This study assessed the effectiveness of intrathecal morphine and patient-controlled analgesia (ITM + PCA) vs patient-controlled analgesia alone (PCA) for postoperative pain management in colorectal cancer surgery. Methods: This retrospective study extracted and analyzed data covering a 4-year period (2014-2018) from a clinical database with 24- and 48-hour postsurgery follow-up. Primary outcomes included pain scores, median opioid consumption (oral morphine equivalence dose), sedation, nausea and vomiting, and length of admission. Outcomes were analyzed for ITM + PCA vs PCA alone, overall and stratified by laparotomy or laparoscopy procedures. Results: In total, 283 patients were included: ITM + PCA (163) and PCA alone (120). Median opioid consumption in the first 24 hours for ITM + PCA vs PCA alone was lower for laparotomy (-32.7 mg, P<0.001) and laparoscopy (-14.3 mg, P<0.001). Median pain score (worst pain) within the first 24 hours for ITM + PCA vs PCA alone was similar for laparotomy (P>0.05) and lower for laparoscopy (-1 unit, P=0.031). Sedation occurred less frequently for ITM + PCA vs PCA at 24 hours (3.5% vs 11.4%, P=0.031), with nonsignificant reduction at 48 hours (4.8% vs 18.8%, P=0.090) for laparotomy, but with no difference for laparoscopy (P>0.05). Incidence of nausea and vomiting and length of admission were similar for ITM + PCA vs PCA alone for laparotomy or laparoscopy (P>0.05). Conclusion: This retrospective study demonstrated that ITM + PCA can achieve similar analgesic effects after laparotomy and laparoscopy colorectal cancer surgery compared with PCA alone while resulting in a reduction of oral opioid consumption and lower incidence of sedation. Keywords: Colorectal; Intrathecal; Morphine; Oncology; Pain; Surgery.en_US
dc.subjectMedical oncologyen_US
dc.subjectRetrospective studiesen_US
dc.subjectPost-operative analgesiaen_US
dc.titleIntrathecal Morphine in Postoperative Analgesia for Colorectal Cancer Surgery: A Retrospective Studyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePain Medicineen_US
dc.description.affiliatesDepartment of Anaesthesia and Pain, Peter MacCallum Cancer Centre, Melbourne, Australiaen_US
dc.description.affiliatesCentre for Integrated Critical Care, University of Melbourne, Melbourne, Australiaen_US
dc.description.affiliatesPharmacy Department, Peter MacCallum Cancer Centre, Melbourne, Australiaen_US
dc.description.affiliatesDepartment of Oncology, University of Melbourne, Parkville, Australiaen_US
dc.contributor.anzcaYoung, Jen_US
Appears in Collections:Scholarly and Clinical

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