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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/920
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dc.contributor.authorJacobson GMen_US
dc.contributor.authorVoss LJen_US
dc.contributor.authorKlockars Aen_US
dc.contributor.authorBird Sen_US
dc.contributor.authorOlszewski PKen_US
dc.contributor.authorSleigh JWen_US
dc.contributor.authorHarvey MGen_US
dc.date2019-04-11-
dc.date.accessioned2020-03-06T03:34:12Z-
dc.date.available2020-03-06T03:34:12Z-
dc.identifier.citation20(1):281en_US
dc.identifier.urihttp://hdl.handle.net/11055/920-
dc.description.abstractBACKGROUND: Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms, broad transcriptome changes were measured and compared across four relevant target regions of the rat brain. RESULTS: SN 35563 produced large-scale alteration of gene expression in the Basolateral Amygdala (BLA) and Paraventricular Nucleus of the Thalamus (PVT), in excess of 10x that induced by ketamine and SN 35210. A smaller and quantitatively similar number of gene changes were observed in the Insula (INS) and Nucleus Accumbens (ACB) for all three agents. In the BLA and PVT, SN 35563 caused enrichment for gene pathways related to the function and structure of glutamatergic synapses in respect to: release of neurotransmitter, configuration of postsynaptic AMPA receptors, and the underlying cytoskeletal scaffolding and alignment. CONCLUSION: The analgesic ketamine ester analog SN 35563 induces profound large-scale changes in gene expression in key pain-related brain regions reflecting its unique prolonged pharmacodynamic profile.en_US
dc.subjectKetamineen_US
dc.subjectTranscriptomeen_US
dc.subjectGlutamateen_US
dc.subjectPotassium channelsen_US
dc.subjectNociceptionen_US
dc.titleTranscriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain.en_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleBMC Genomicsen_US
dc.identifier.doi10.1186/s12864-019-5649-6en_US
dc.description.affiliatesThe University of Waikatoen_US
dc.description.affiliatesWaikato District Health Boarden_US
dc.description.affiliatesThe University of Aucklanden_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/30971208en_US
dc.type.studyortrialStudyen_US
dc.ispartof.anzcaresearchfoundationYesen_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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