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dc.contributor.authorReid DBen_US
dc.contributor.authorChapple LSen_US
dc.contributor.authorO'Connor SNen_US
dc.contributor.authorBellomo Ren_US
dc.contributor.authorBuhr Hen_US
dc.contributor.authorChapman MJen_US
dc.contributor.authorDavies ARen_US
dc.contributor.authorEastwood GMen_US
dc.contributor.authorFerrie Sen_US
dc.contributor.authorLange Ken_US
dc.contributor.authorMcIntyre Jen_US
dc.contributor.authorNeedham DMen_US
dc.contributor.authorPeake SLen_US
dc.contributor.authorRai Sen_US
dc.contributor.authorRidley EJen_US
dc.contributor.authorRodgers Hen_US
dc.description.abstractAugmenting energy delivery during the acute phase of critical illness may reduce mortality and improve functional outcomes. The objective of this sub-study was to evaluate the effect of early augmented enteral nutrition (EN) during critical illness, on outcomes one year later. We performed prospective longitudinal evaluation of study participants, initially enrolled in The Augmented versus Routine approach to Giving Energy Trial (TARGET), a feasibility study that randomised critically ill patients to 1.5 kcal/ml (augmented) or 1.0 kcal/ml (routine) EN administered at the same rate for up to ten days, who were alive at one year. One year after randomisation Short Form-36 version 2 (SF-36v2) and EuroQol-5D-5L quality of life surveys, and employment status were assessed via telephone survey. At one year there were 71 survivors (1.5 kcal/ml 38 versus 1.0 kcal/ml 33; P=0.55). Thirty-nine (55%) patients consented to this follow-up study and completed the surveys (n = 23 and 16, respectively). The SF-36v2 physical and mental component summary scores were below normal population means but were similar in 1.5 kcal/ml and 1.0 kcal/ml groups (P=0.90 and P=0.71). EuroQol-5D-5L data were also comparable between groups (P=0.70). However, at one-year follow-up, more patients who received 1.5 kcal/ml were employed (7 versus 2; P=0.022). The delivery of 1.5 kcal/ml for a maximum of ten days did not affect self-rated quality of life one year later.en_US
dc.subjectcritical illnessen_US
dc.subjectpost–intensive care syndromeen_US
dc.subjectquality of lifeen_US
dc.titleThe effect of augmenting early nutritional energy delivery on quality of life and employment status one year after ICU admissionen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAnaesthesia and Intensive Careen_US
dc.type.studyortrialObservational studyen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
Appears in Collections:Scholarly and Clinical
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