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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/881
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dc.contributor.authorKinfe TMen_US
dc.contributor.authorBuchfelder Men_US
dc.contributor.authorChaudhry SRen_US
dc.contributor.authorChakravarthy KVen_US
dc.contributor.authorDeer TRen_US
dc.contributor.authorRusso Men_US
dc.contributor.authorGeorgius Pen_US
dc.contributor.authorHurlemann Ren_US
dc.contributor.authorRasheed Men_US
dc.contributor.authorMuhammad Sen_US
dc.contributor.authorYearwood TLen_US
dc.date2019-09-24-
dc.date.accessioned2019-10-17T00:42:57Z-
dc.date.available2019-10-17T00:42:57Z-
dc.date.issued2019-10-
dc.identifier.citation20(19). pii: E4737en_US
dc.identifier.urihttp://hdl.handle.net/11055/881-
dc.description.abstractChronic pain is a devastating condition affecting the physical, psychological, and socioeconomic status of the patient. Inflammation and immunometabolism play roles in the pathophysiology of chronic pain disorders. Electrical neuromodulation approaches have shown a meaningful success in otherwise drug-resistant chronic pain conditions, including failed back surgery, neuropathic pain, and migraine. A literature review (PubMed, MEDLINE/OVID, SCOPUS, and manual searches of the bibliographies of known primary and review articles) was performed using the following search terms: chronic pain disorders, systemic inflammation, immunometabolism, prediction, biomarkers, metabolic disorders, and neuromodulation for chronic pain. Experimental studies indicate a relationship between the development and maintenance of chronic pain conditions and a deteriorated immunometabolic state mediated by circulating cytokines, chemokines, and cellular components. A few uncontrolled in-human studies found increased levels of pro-inflammatory cytokines known to drive metabolic disorders in chronic pain patients undergoing neurostimulation therapies. In this narrative review, we summarize the current knowledge and possible relationships of available neurostimulation therapies for chronic pain with mediators of central and peripheral neuroinflammation and immunometabolism on a molecular level. However, to address the needs for predictive factors and biomarkers, large-scale databank driven clinical trials are needed to determine the clinical value of molecular profiling.en_US
dc.subjectChronic Painen_US
dc.subjectneuromodulationen_US
dc.subjectsystemic inflammationen_US
dc.subjectbiomarkers developmenten_US
dc.subjectimmunometabolismen_US
dc.subjectquantitative outcome measuresen_US
dc.titleLeptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Painen_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleInternational Journal of Molecular Sciencesen_US
dc.identifier.doi10.3390/ijms20194737en_US
dc.description.affiliatesDepartment of Neurosurgery, Division of Functional Neurosurgery and Stereotaxy, University of Erlangen-Nuerembergen_US
dc.description.affiliatesDepartment of Basic Medical Sciences Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat Universityen_US
dc.description.affiliatesDepartment of Anesthesiology and Pain Medicine, University of Californiaen_US
dc.description.affiliatesVA San Diego Healthcare Systemen_US
dc.description.affiliatesThe Spine and Nerve Center of the Virginiasen_US
dc.description.affiliatesHunter Pain Clinicen_US
dc.description.affiliatesNambour Selangor Private Hospitalen_US
dc.description.affiliatesDepartment of Psychiatry, Division of Medical Psychology, University Hospital Bonnen_US
dc.description.affiliatesDepartment of Neuro-Urology Marien Hospital Herne, University Clinic of the Ruhr University Bochumen_US
dc.description.affiliatesDepartment of Neurosurgery, University Hospital Duesseldorfen_US
dc.description.affiliatesNeuromodulation Specialists LLCen_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/31554241en_US
dc.type.studyortrialNarrative Reviewsen_US
local.message.claim2023-05-02T12:05:54.601+1000|||rp00166|||submit_approve|||dc_contributor_author|||None*
dc.type.specialtyPain Medicineen_US
dc.identifier.fulltextlinkhttps://www.mdpi.com/1422-0067/20/19/4737en_US
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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