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dc.contributor.authorMiles LFen_US
dc.contributor.authorSandhu RNen_US
dc.contributor.authorGrobler ACen_US
dc.contributor.authorHeritier Sen_US
dc.contributor.authorBurgess Aen_US
dc.contributor.authorBurbury KLen_US
dc.contributor.authorStory, DAen_US
dc.identifier.citationAnaesth Intensive Care. 2019 May 15:310057X19838899en_US
dc.description.abstractIron deficiency is common in colorectal cancer. Despite perioperative guidelines advocating for the correction of non-anaemic iron deficiency prior to major surgery, the impact of this pathology on postoperative outcome is unclear. We conducted a single-centre, historical cohort study of 141 elective resections for colorectal cancer. We stratified non-anaemic patients into iron deficient and iron replete groups, and collected data on baseline characteristics, preoperative laboratory results, intraoperative events and postoperative outcomes. As this study was an exploratory work for future research, a P-value of 0.25 was considered relevant. Patients in the deficient group demonstrated lower baseline ferritin (median (interquartile range, IQR) 76 (41-141) µg/L versus 207 (140-334) µg/L, P < 0.001) and transferrin saturation (mean (standard deviation, SD) 18% (8%) versus 32% (12%), P < 0.001) than those in the replete group, and lower starting haemoglobin (mean (SD) 138 (10) g/L versus 144 (12) g/L, P = 0.01). The deficient group had increased re-admission (25% (24%) versus 4% (11%), P = 0.15) and all-cause infection (25% (24%) versus 5% (14%), P = 0.24). A decrease of two days in days alive and out of hospital at postoperative day 90 was seen in the deficient group on univariate analysis (median (IQR) 81 (75-84) versus 83 (78-84), P = 0.25). This reduced to 1.24 days in multivariate adjusted quantile regression analysis ( P = 0.22). Days alive and out of hospital at day 90, postoperative re-admission and postoperative infection may be meaningful outcome measures for future prospective observational work examining non-anaemic iron deficiency in patients undergoing major surgery for colorectal cancer.en_US
dc.subjectcolonic neoplasmsen_US
dc.subjectelective surgical proceduresen_US
dc.titleAssociations between non-anaemic iron deficiency and outcomes following surgery for colorectal cancer: An exploratory study of outcomes relevant to prospective observational studiesen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAnaesth Intensive Careen_US
dc.description.affiliatesDepartment of Anaesthesia, Austin Health, Melbourne, Australia.en_US
dc.description.affiliatesCentre for Integrated Critical Care, Melbourne Medical School, University of Melbourne, Australia.en_US
dc.description.affiliatesMurdoch Children's Research Institute, Melbourne, Australia.en_US
dc.description.affiliatesDepartment of Epidemiology and Preventative Medicine, Monash University, Melbourne, Australiaen_US
dc.description.affiliatesDepartment of Colorectal Surgery, Austin Health, Melbourne, Australiaen_US
dc.description.affiliatesDivision of Haematology, Victorian Comprehensive Cancer Centre, Melbourne, Australia.en_US
dc.type.studyortrialClinical Trialen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
Appears in Collections:Scholarly and Clinical
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