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dc.contributor.authorNaylor Ren_US
dc.contributor.authorHayes Cen_US
dc.contributor.authorEgger Gen_US
dc.description.abstractChronic pain has a significant economic and social impact on the community. The most common medical treatments for it include paracetamol, anti-inflammatory agents, and opioid analgesics. However, many of these medications cause side effects, and their long-term effectiveness is questionable. The traditional alternative to the biomedical approach is cognitive behavioral therapy. However, this has also been shown in recent studies to have only modest benefit. It is becoming clear that the effective management of chronic pain requires a more holistic, systems-based approach, hence the emerging interest in the relationship between pain and lifestyle. The authors aim to review the literature regarding the relationship between comprehensive lifestyle changes, markers of systemic inflammation, and the perception of chronic pain. An extensive search of bibliographic databases, including MEDLINE, PubMed, Web of Science, and Cochrane Library databases was made. A total of 2197 articles were identified using the search strategy. Only 44 articles were retrieved for critical appraisal, of which only 2 studies met the prespecified primary inclusion criteria and were included in the final review. These data provided some evidence that a single lifestyle factor (sleep restriction or disturbance) can produce elevated levels of interleukin-6, which is associated with higher pain intensity ratings. However, this review has highlighted a paucity of research based around the relationship between lifestyle, metaflammation, and chronic pain. There is a clear need for well-designed trials examining comprehensive lifestyle interventions and their effect on both pain intensity and markers of metaflammation.en_US
dc.subjectChronic Painen_US
dc.subjectanti-inflammatory agentsen_US
dc.subjectcognitive therapyen_US
dc.subjectlife styleen_US
dc.titleThe relationship between lifestyle, metaflammation and chronic pain: a systematic reviewen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAmerican Journal of Lifestyle Medicineen_US
dc.type.studyortrialSystematic Reviewsen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
Appears in Collections:Scholarly and Clinical
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