AIRR - ANZCA Institutional Research Repository
Skip navigation
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChen SSMen_US
dc.contributor.authorLeeton Len_US
dc.contributor.authorCastro JMen_US
dc.contributor.authorDennis ATen_US
dc.identifier.citation2018 Aug 2. pii: S0959-289X(18)30146-8 [Epub ahead of print]en_US
dc.description.abstractBACKGROUND: Pre-eclampsia is characterised by increased left ventricular wall thickness on transthoracic echocardiography (TTE). This is assumed to be myocardial hypertrophy, however TTE cannot determine myocardial structure which may be muscle, oedema or fibrosis. Given the high incidence of peripheral oedema in pre-eclampsia, we hypothesised that increased thickness could represent oedema. Cardiovascular magnetic resonance (CMR) characterises myocardial tissue, differentiating between hypertrophy, oedema and fibrosis. This pilot study was designed to characterise myocardial composition using CMR in pregnant women (healthy or with pre-eclampsia) and to compare cardiac output and left ventricular mass using TTE and CMR. METHODS: Thirty-six women (31 healthy, five with pre-eclampsia) underwent TTE and CMR and left ventricular mass was assessed applying standard definitions. Myocardial signal intensities were measured from left ventricular segments and compared to serratus anterior muscle to determine global myocardial signal intensity. Myocardial oedema was defined as a myocardial:skeletal signal intensity ratio >1.9. Agreement between devices for cardiac output and left ventricular mass, and inter- and intra-observer measurements used Bland Altman methodology, calculating the agreement tolerable interval: >1.5 is unacceptable, 1.0-1.5 is marginal and <1.0 is acceptable agreement. RESULTS: Myocardial oedema was present in two (40%) pre-eclamptic women but no healthy women (P=0.017). Agreement for cardiac output was acceptable, for left ventricular mass marginal, and for inter- and intra-observer measurements acceptable. CONCLUSIONS: Cardiovascular magnetic resonance was used to characterise the myocardial tissue in women with pre-eclampsia. Data suggest that some women with pre-eclampsia have myocardial oedema rather than hypertrophy.en_US
dc.subjectcardiovascular magnetic resonanceen_US
dc.subjectmyocardial oedemaen_US
dc.titleMyocardial tissue characterisation and detection of myocardial oedema by cardiovascular magnetic resonance in women with pre-eclampsia: a pilot studyen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInternational Journal of Obstetric Anesthesiaen_US
dc.description.affiliatesRoyal Women's Hospital, Parkville, Australiaen_US
dc.description.affiliatesThe University of Melbourne, Parkville, Australiaen_US
dc.type.studyortrialPilot/Feasibility Studyen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
Appears in Collections:Scholarly and Clinical
Show simple item record

Page view(s)

checked on Jan 12, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.