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https://hdl.handle.net/11055/604
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DC Field | Value | Language |
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dc.contributor.author | Myles, PS | en_US |
dc.contributor.author | Leslie, K | en_US |
dc.contributor.author | McNeil, J | en_US |
dc.contributor.author | Forbes, A | en_US |
dc.contributor.author | Chan, MTV | en_US |
dc.date.accessioned | 2018-06-20T03:35:11Z | - |
dc.date.available | 2018-06-20T03:35:11Z | - |
dc.date.issued | 2004-05 | - |
dc.identifier.citation | 363(9423):1757-63. | en_US |
dc.identifier.uri | http://hdl.handle.net/11055/604 | - |
dc.description.abstract | BACKGROUND: Awareness is an uncommon complication of anaesthesia, affecting 0.1-0.2% of all surgical patients. Bispectral index (BIS) monitoring measures the depth of anaesthesia and facilitates anaesthetic titration. In this trial we determined whether BIS-guided anaesthesia reduced the incidence of awareness during surgery in adults. METHODS: We did a prospective, randomised, double-blind, multicentre trial. Adult patients at high risk of awareness were randomly allocated to BIS-guided anaesthesia or routine care. Patients were assessed by a blinded observer for awareness at 2-6 h, 24-36 h, and 30 days after surgery. An independent committee, blinded to group identity, assessed every report of awareness. The primary outcome measure was confirmed awareness under anaesthesia at any time. FINDINGS: Of 2463 eligible and consenting patients, 1225 were assigned to the BIS group and 1238 to the routine care group. There were two reports of awareness in the BIS-guided group and 11 reports in the routine care group (p=0.022). BIS-guided anaesthesia reduced the risk of awareness by 82% (95% CI 17-98%). INTERPRETATION: BIS-guided anaesthesia reduces the risk of awareness in at-risk adult surgical patients undergoing relaxant general anaesthesia. With a cost of routine BIS monitoring at US16 dollars per use in Australia and a number needed to treat of 138, the cost of preventing one case of awareness in high-risk patients is about 2200 dollars. | en_US |
dc.title | Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial. | en_US |
dc.type | Journal Article | en_US |
dc.type.content | Text | en_US |
dc.identifier.journaltitle | Lancet | en_US |
dc.description.affiliates | The Alfred Hospital | en_US |
dc.description.pubmeduri | https://www.ncbi.nlm.nih.gov/pubmed/15172773 | en_US |
dc.type.studyortrial | Randomized Controlled Clinical Trial/Controlled Clinical Trial | en_US |
dc.identifier.studyname | B-Aware Trial | en_US |
dc.ispartof.anzcaresearchfoundation | Yes | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
Appears in Collections: | Scholarly and Clinical |
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