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dc.contributor.authorMyles, PSen_US
dc.contributor.authorBoney, Oen_US
dc.contributor.authorBotti, Men_US
dc.contributor.authorCyna, AMen_US
dc.contributor.authorGan, TJen_US
dc.contributor.authorJensen, MPen_US
dc.contributor.authorKehlet, Hen_US
dc.contributor.authorKurz, Aen_US
dc.contributor.authorDe Oliveira, GS Jren_US
dc.contributor.authorPeyton, Pen_US
dc.contributor.authorSessler, DIen_US
dc.contributor.authorTramèr, MRen_US
dc.contributor.authorWu, CLen_US
dc.contributor.authorStEP–COMPAC Groupen_US
dc.contributor.authorMyles, Pen_US
dc.contributor.authorGrocott, Men_US
dc.contributor.authorBiccard, Ben_US
dc.contributor.authorBlazeby, Jen_US
dc.contributor.authorBoney, Oen_US
dc.contributor.authorChan, Men_US
dc.contributor.authorDiouf, Een_US
dc.contributor.authorFleisher, Len_US
dc.contributor.authorKalkman, Cen_US
dc.contributor.authorKurz, Aen_US
dc.contributor.authorMoonesinghe, Ren_US
dc.contributor.authorWijeysundera, Den_US
dc.description.abstractBACKGROUND: Maximising patient comfort during and after surgery is a primary concern of anaesthetists and other perioperative clinicians, but objective measures of what constitutes patient comfort in the perioperative period remain poorly defined. The Standardised Endpoints in Perioperative Medicine initiative was established to derive a set of standardised endpoints for use in perioperative clinical trials. METHODS: We undertook a systematic review to identify measures of patient comfort used in the anaesthetic, surgical, and other perioperative literature. A multi-round Delphi consensus process that included up to 89 clinician researchers was then used to refine a recommended list of outcome measures. RESULTS: We identified 122 studies in a literature search, which were the basis for a preliminary list of 24 outcome measures and their definitions. The response rates for Delphi Rounds 1, 2, and 3 were 100% (n=22), 90% (n=79), and 100% (n=13), respectively. A final list of six defined endpoints was identified: pain intensity (at rest and during movement) at 24 h postoperatively, nausea and vomiting (0-6 h, 6-24 h, and overall), one of two quality-of-recovery (QoR) scales (QoR score or QoR-15), time to gastrointestinal recovery, time to mobilisation, and sleep quality. CONCLUSIONS: As standardised outcomes will support benchmarking and pooling (meta-analysis) of trials, one or more of these recommended endpoints should be considered for inclusion in clinical trials assessing patient comfort and pain after surgeryen_US
dc.subjectstandardised endpoints, perioperative medicine, systematic reviewen_US
dc.titleSystematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: patient comfort.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBritish Journal of Anaesthesiaen_US
dc.type.studyortrialSystematic Reviewsen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
Appears in Collections:Scholarly and Clinical
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