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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/589
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dc.contributor.authorBenson Men_US
dc.contributor.authorMarangou Aen_US
dc.contributor.authorRusso Men_US
dc.contributor.authorDurocher Jen_US
dc.contributor.authorCollaku Aen_US
dc.contributor.authorStarkey YYen_US
dc.date2009-10-01-
dc.date.accessioned2018-06-15T01:42:32Z-
dc.date.available2018-06-15T01:42:32Z-
dc.date.issued2009-10-01-
dc.identifier.citation37(5):1321-1335en_US
dc.identifier.urihttp://hdl.handle.net/11055/589-
dc.description.abstractGuidelines for osteoarthritis (OA) management recommend paracetamol (acetaminophen) as the most appropriate first-line analgesic for mild to moderate pain. Standard paracetamol requires four times daily dosing. Drug compliance and convenience are inversely related to daily dose frequency. Compliance is a pivotal component of the successful management of OA pain and is influenced by patient preferences or beliefs. The added convenience of three times daily dosing may enhance compliance and, therefore, pain relief. This multicentre, randomized, open-label, two-way crossover, phase IV study is the first to evaluate patient preference with a sustained-release paracetamol tablet formulation designed for three times daily dosing. Compared with standard paracetamol tablets dosed four times daily, the sustained-release formulation was preferred in a 2:1 ratio, provided better overall joint pain relief, resulted in higher levels of satisfaction in subjects with OA of the knee and has the potential to improve patient compliance and, therefore, pain control.en_US
dc.subjectparacetamolen_US
dc.subjectAcetaminophenen_US
dc.subjectkneeen_US
dc.subjectosteoarthritisen_US
dc.subjectpatient preferenceen_US
dc.subjectcomplianceen_US
dc.titlePatient Preference for Sustained-Release versus Standard Paracetamol (Acetaminophen): A Multicentre, Randomized, Open-Label, Two-Way Crossover Study in Subjects with Knee Osteoarthritisen_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleThe Journal of International Medical Researchen_US
dc.identifier.doi10.1177/147323000903700507en_US
dc.description.affiliatesCaptain Stirling Medical Centreen_US
dc.description.affiliatesSwan Valley Primary Care and Research Centreen_US
dc.description.affiliatesHunter Clinical Researchen_US
dc.description.affiliatesGlaxoSmithKilneen_US
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/19930837en_US
dc.type.studyortrialRandomized Controlled Clinical Trial/Controlled Clinical Trialen_US
dc.ispartof.anzcaresearchfoundationYesen_US
local.message.claim2023-05-02T12:05:54.601+1000|||rp00166|||submit_approve|||dc_contributor_author|||None*
dc.type.specialtyAnaesthesiaen_US
item.cerifentitytypePublications-
item.grantfulltextreserved-
item.openairetypeJournal Article-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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