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Title: Meaningful relief with flurbiprofen 8.75 mg spray in patients with sore throat due to upper respiratory tract infection
Authors: de Looze F
Russo M 
Bloch M
Montgomery B
Shephard A
DeVito R
Keywords: flurbiprofen
sore throat
Issue Date: Mar-2018
Source: 8(2):79-83
Journal Title: Pain Management
Abstract: AIM: Evaluate the efficacy of flurbiprofen 8.75 mg spray for sore throat relief. PATIENTS & METHODS: Randomized, double-blind study in adults with sore throat due to upper respiratory tract infection who took flurbiprofen (n = 249) or placebo spray (n = 256). Pain relief was assessed using the Sore Throat Relief Rating Scale. RESULTS: Flurbiprofen spray provided significantly greater relief versus placebo from 20 min to 6 h (p < 0.0001; maximum difference: 75 min). Sore throat severity was reduced ≥-2.2 on the Sore Throat Scale from 75 min to 6 h, indicating meaningful relief. Significantly more patients taking flurbiprofen spray reported ≥30 min of 'at least moderate' relief versus placebo over 6 h (p < 0.0001). Most adverse events were mild. CONCLUSION: Flurbiprofen spray provides rapid, long-lasting and clinically meaningful relief from sore throat (ANZCTR: ACTRN12612000457842).
DOI: 10.2217/pmt-2017-0100
PubMed URL:
ISSN: 1758-1869
Grant Name: ACTRN12612000457842
Type: Journal Article
Affiliates: AusTrials Pty Ltd, Sherwood, QLD, Australia
School of Medicine, University of Queensland, Brisbane, QLD, Australia
Hunter Clinical Research, Broadmeadow, Newcastle, NSW, Australia
Holdsworth House Medical Practice, Darlinghurst, NSW, Australia
Optimal Clinical Trials, Auckland, New Zealand
Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK
Reckitt Benckiser, Parsippany, NJ 07054-0225, USA
Study/Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
Appears in Collections:Scholarly and Clinical

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