AIRR - ANZCA Institutional Research Repository
Skip navigation
Please use this identifier to cite or link to this item:
Title: Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis.
Authors: Afsharimani, B
Doornebal, C W
Cabot, P J
Hollmann, M W
Parat, M-O
Issue Date: Jan-2015
Source: British journal of pharmacology 2015-01; 172(2): 251-9
Abstract: The effect of opioids on tumour growth and metastasis has been debated for many years, with recent emphasis on the possibility that they might influence the rate of disease-free survival after tumour resection when used in the perioperative pain management of cancer surgery patients. The literature presents conflicting and inconclusive in vitro and in vivo data about the potential effect of opioids, especially morphine, on tumour growth and metastasis. To inform clinical practice, appropriate animal models are needed to test whether opioids alter the course of tumour growth and metastasis. Here, we review the literature on animal-based studies testing the effect of morphine on cancer so far, and analyse differences between the models used that may explain the discrepancies in published results. Such analysis should elucidate the role of opioids in cancer and help define ideal pre-clinical models to provide definitive answers. This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit
DOI: 10.1111/bph.12589
PubMed URL:
Journal Title: British journal of pharmacology
Type: Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Appears in Collections:Scholarly and Clinical

Show full item record

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.