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Title: Opioid analgesic agents and cancer cell biology
Authors: Xie, N
Parat, M-O
Keywords: cancer
Cancer cell proliferation
Opioid receptor
Issue Date: Sep-2015
Source: 5: 278
Abstract: There is growing interest in the notion that perioperative factors may influence the long-term outcome of cancer surgery. Among these factors, pharmacologic agents including anesthetics and analgesics have been scrutinized for their potential effect on tumors. Opioids are particularly interesting in this context, as conflicting literature reports both pro- and anti-tumor effects for this class of drugs in every aspect of tumor growth and metastasis that has been examined. Cancer and non-cancer cells important to the tumor biology may be affected, as demonstrated using a variety of in vitro and preclinical models. More evidence is required to optimize the perioperative pain management of cancer surgery patients.
DOI: 10.1007/s40140-015-0118-5
PubMed URL:
ISSN: 2167-6275
Journal Title: Current Anesthesiology Reports
Type: Journal Article
Affiliates: Australian and New Zealand College of Anaesthetists
Appears in Collections:Scholarly and Clinical

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