Please use this identifier to cite or link to this item:
https://hdl.handle.net/11055/204
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Peake, Sandra L | - |
dc.contributor.author | Davies, Andrew R | - |
dc.contributor.author | Deane, Adam M | - |
dc.contributor.author | Lange, Kylie | - |
dc.contributor.author | Moran, JL | - |
dc.contributor.author | O'Connor, Stephanie N | - |
dc.contributor.author | Ridley, Emma J | - |
dc.contributor.author | Williams, Patricia J | - |
dc.contributor.author | Chapman, MJ | - |
dc.date | 2014 | - |
dc.date.accessioned | 2018-03-08T00:48:42Z | - |
dc.date.available | 2018-03-08T00:48:42Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.citation | The American journal of clinical nutrition 2014-08; 100(2): 616-25 | - |
dc.identifier.uri | http://hdl.handle.net/11055/204 | - |
dc.description.abstract | Critically ill patients typically receive ∼60% of estimated calorie requirements. We aimed to determine whether the substitution of a 1.5-kcal/mL enteral nutrition solution for a 1.0-kcal/mL solution resulted in greater calorie delivery to critically ill patients and establish the feasibility of conducting a multicenter, double-blind, randomized trial to evaluate the effect of an increased calorie delivery on clinical outcomes. A prospective, randomized, double-blind, parallel-group, multicenter study was conducted in 5 Australian intensive care units. One hundred twelve mechanically ventilated patients expected to receive enteral nutrition for ≥2 d were randomly assigned to receive 1.5 (n = 57) or 1.0 (n = 55) kcal/mL enteral nutrition solution at a rate of 1 mL/kg ideal body weight per hour for 10 d. Protein and fiber contents in the 2 solutions were equivalent. The 2 groups had similar baseline characteristics (1.5 compared with 1.0 kcal/mL). The mean (±SD) age was 56.4 ± 16.8 compared with 56.5 ± 16.1 y, 74% compared with 75% were men, and the Acute Physiology and Chronic Health Evaluation II score was 23 ± 9.1 compared with 22 ± 8.9. The groups received similar volumes of enteral nutrition solution [1221 mL/d (95% CI: 1120, 1322 mL/d) compared with 1259 mL/d (95% CI: 1143, 1374 mL/d); P = 0.628], which led to a 46% increase in daily calories in the group given the 1.5-kcal/mL solution [1832 kcal/d (95% CI: 1681, 1984 kcal/d) compared with 1259 kcal/d (95% CI: 1143, 1374 kcal/d); P < 0.001]. The 1.5-kcal/mL solution was not associated with larger gastric residual volumes or diarrhea. In this feasibility study, there was a trend to a reduced 90-d mortality in patients given 1.5 kcal/mL [11 patients (20%) compared with 20 patients (37%); P = 0.057]. The substitution of a 1.0- with a 1.5-kcal/mL enteral nutrition solution administered at the same rate resulted in a 46% greater calorie delivery without adverse effects. The results support the conduct of a large-scale trial to evaluate the effect of increased calorie delivery on clinically important outcomes in the critically ill. | - |
dc.language.iso | eng | - |
dc.subject.mesh | APACHE | - |
dc.subject.mesh | Aged | - |
dc.subject.mesh | Australia | - |
dc.subject.mesh | Cohort Studies | - |
dc.subject.mesh | Double-Blind Method | - |
dc.subject.mesh | Hospitals, University | - |
dc.subject.mesh | Ideal Body Weight | - |
dc.subject.mesh | Intensive Care Units | - |
dc.subject.mesh | Middle Aged | - |
dc.subject.mesh | Respiration, Artificial | - |
dc.subject.mesh | Survival Analysis | - |
dc.subject.mesh | Critical Care | - |
dc.subject.mesh | Energy Intake | - |
dc.subject.mesh | Enteral Nutrition | - |
dc.subject.mesh | Food, Formulated | - |
dc.title | Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial. | - |
dc.type | Journal Article | - |
dc.type | Randomized Controlled Trial | - |
dc.type | Research Support, Non-U.S. Gov't | - |
dc.identifier.journaltitle | The American journal of clinical nutrition | - |
dc.identifier.doi | 10.3945/ajcn.114.086322 | - |
dc.description.pubmeduri | https://www.ncbi.nlm.nih.gov/pubmed/24990423 | - |
dc.identifier.pubmedid | 24990423 | - |
dc.ispartof.anzcaresearchfoundation | Yes | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Journal Article | - |
item.openairetype | Randomized Controlled Trial | - |
item.openairetype | Research Support, Non-U.S. Gov't | - |
item.grantfulltext | none | - |
Appears in Collections: | Scholarly and Clinical |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.