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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/1288
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dc.contributorRusso Men_US
dc.contributorChakravarthy Ken_US
dc.contributorKinfe TMen_US
dc.contributor.authorStaats PSen_US
dc.contributor.authorAyata Cen_US
dc.contributor.authorLerman Ien_US
dc.contributor.authorAbd-Elsayed Aen_US
dc.date2024-12-
dc.date.accessioned2025-01-20T23:45:45Z-
dc.date.available2025-01-20T23:45:45Z-
dc.date.issued2025-
dc.identifier.isbn978-0-12-816996-4en_US
dc.identifier.urihttps://hdl.handle.net/11055/1288-
dc.descriptionAbstract The vagus nerve, a crucial component of the parasympathetic nervous system, plays a pivotal role in regulating autonomic balance. Originating in the brain stem, it serves as a link between the higher brain centers, autonomic nervous system, central and peripheral nervous systems, immune system, and visceral organs through extensive branching and afferent/efferent innervation. Vagus nerve stimulation (VNS) has proven effective in treating refractory epilepsy and treatment-resistant depression, while also showing promise in managing chronic pain. Its potential analgesic effects have been demonstrated in animals, with comparable effects documented in epilepsy patients with implanted VNS devices. Further support comes from experimental pain studies in healthy humans and neuroimaging studies. Potential benefits have also been explored in primary headache disorders, fibromyalgia, visceral and pelvic pain, and other pain conditions using modern noninvasive systems. Proposed mechanisms for the analgesic effects of VNS include activation of the cholinergic antiinflammatory pathway and modulation of spinal nociceptive transmission. Future research may focus on central sensitization states and pain conditions in which widespread brain-immune interaction is involved.en_US
dc.publisherAcademic Pressen_US
dc.titleVagus Nerve Stimulationen_US
dc.title.alternativeChapter 15 - Vagus nerve stimulation for the management of chronic painen_US
dc.typeBook Chapteren_US
dc.type.contentTexten_US
dc.publisher.placeLondon, U.Ken_US
dc.identifier.doi10.1016/B978-0-12-816996-4.00007-1en_US
dc.description.affiliatesHunter Pain Specialists, Broadmeadow, NSW, Australiaen_US
dc.description.affiliatesGenesis Research Services, Broadmeadow, NSW, Australiaen_US
dc.description.affiliatesSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australiaen_US
dc.description.affiliatesDepartment of Anesthesiology, University of California, San Diego, CA, United Statesen_US
dc.description.affiliatesDivision of Functional Neurosurgery and Stereotaxy, Department of Neurosurgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germanyen_US
dc.type.specialtyAnaesthesiaen_US
dc.type.specialtyPain Medicineen_US
dc.identifier.fulltextlinkhttps://www.sciencedirect.com/science/article/abs/pii/B9780128169964000071en_US
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairetypeBook Chapter-
Appears in Collections:Scholarly and Clinical
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