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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/1222
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dc.contributor.authorEccleston Cen_US
dc.contributor.authorFisher Een_US
dc.contributor.authorCooper TEen_US
dc.contributor.authorGrégoire MCen_US
dc.contributor.authorKrane Een_US
dc.contributor.authorLord SMen_US
dc.contributor.authorSethna NFen_US
dc.contributor.authorAnderson AKen_US
dc.contributor.authorAnderson Ben_US
dc.contributor.authorClinch Jen_US
dc.contributor.authorGray ALen_US
dc.contributor.authorGold JIen_US
dc.contributor.authorHoward RFen_US
dc.contributor.authorLjungman Gen_US
dc.contributor.authorMoore RAen_US
dc.contributor.authorSchechter Nen_US
dc.contributor.authorWiffen PJen_US
dc.contributor.authorWilkinson NMRen_US
dc.contributor.authorWilliams DGen_US
dc.contributor.authorWood Cen_US
dc.contributor.authorvan Tilburg MALen_US
dc.contributor.authorZernikow Ben_US
dc.date.accessioned2024-07-23T03:43:08Z-
dc.date.available2024-07-23T03:43:08Z-
dc.date.issued2019-08-
dc.identifier.citation160(8):1698-1707.en_US
dc.identifier.issn0304-3959en_US
dc.identifier.urihttps://hdl.handle.net/11055/1222-
dc.description.abstractWe know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) or chronic cancer-related pain (CCRP). We searched the Cochrane Database of Systematic Reviews, Medline, EMBASE, and DARE for systematic reviews from inception to March 2018. We conducted reference and citation searches of included reviews. We included children (0-18 years of age) with CNCP or CCRP. We extracted the review characteristics and primary outcomes of ≥30% participant-reported pain relief and patient global impression of change. We sifted 704 abstracts and included 23 systematic reviews investigating children with CNCP or CCRP. Seven of those 23 reviews included 6 trials that involved children with CNCP. There were no randomised controlled trials in reviews relating to reducing pain in CCRP. We were unable to combine data in a meta-analysis. Overall, the quality of evidence was very low, and we have very little confidence in the effect estimates. The state of evidence of randomized controlled trials in this field is poor; we have no evidence from randomised controlled trials for pharmacological interventions in children with cancer-related pain, yet cannot deny individual children access to potential pain relief. Prospero ID: CRD42018086900.en_US
dc.subjectchronic painen_US
dc.subjectpharmacologyen_US
dc.subjectchilden_US
dc.subjectadolescenceen_US
dc.titlePharmacological interventions for chronic pain in children: an overview of systematic reviewsen_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitlePainen_US
dc.identifier.doi10.1097/j.pain.0000000000001609en_US
dc.description.affiliatesCentre for Pain Research, University of Bath, Bath, United Kingdomen_US
dc.description.affiliatesDepartment of Clinical and Health Psychology, Ghent University, Ghent, Belgiumen_US
dc.description.affiliatesPain, Palliative, and Supportive Care, Oxford University Hospitals, Oxford, United Kingdomen_US
dc.description.affiliatesFaculty of Medicine and Health, School of Public Health, The University of Sydney, Sydney, New South Wales, Australiaen_US
dc.description.affiliatesDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canadaen_US
dc.description.affiliatesDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United Statesen_US
dc.description.affiliatesDepartment of Anesthesiology, Perioperative, and Pain Medicine, Pediatrics, Stanford University School of Medicine, Stanford, Palo Alto, CA, United Statesen_US
dc.description.affiliatesChildren's Complex Pain Service, John Hunter Children's Hospital, Hunter Medical Research Institute, Newcastle, New South Wales, Australiaen_US
dc.description.affiliatesFaculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australiaen_US
dc.description.affiliatesDepartment of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA, United Statesen_US
dc.description.affiliatesRoyal Marsden Hospital, London, United Kingdomen_US
dc.description.affiliatesDepartment of Anaesthesiology, University of Auckland, Auckland, New Zealanden_US
dc.description.affiliatesBristol Royal Children's Hospital, University of Bristol, Bristol, United Kingdomen_US
dc.description.affiliatesRoyal National Hospital for Rheumatic Diseases, Bath, United Kingdomen_US
dc.description.affiliatesDivision of Pharmacology, Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, South Africaen_US
dc.description.affiliatesAnesthesiology, Pediatrics, and Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United Statesen_US
dc.description.affiliatesPediatric Pain Management Clinic, Children's Hospital Los Angeles, Los Angeles, CA, United Statesen_US
dc.description.affiliatesDepartment of Anaesthesia and Pain Medicine, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdomen_US
dc.description.affiliatesPediatric Oncology, Department of Women's and Children's Health, Uppsala University, Uppsala, Swedenen_US
dc.description.affiliatesPain Research, Nuffield, Department of Clinical Neurosciences, University of Oxford, The Churchill, Oxford, United Kingdomen_US
dc.description.affiliatesDepartment of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United Statesen_US
dc.description.affiliatesDepartment of Paediatrics, Evelina London Children's Hospital, Kings College London, United Kingdomen_US
dc.description.affiliatesThe Anaesthetic Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdomen_US
dc.description.affiliatesDepartment of Rheumatology, Chronic Pain Centre, University Hospital of Limoges, University of Limoges, Haute Vienne, Franceen_US
dc.description.affiliatesCollege of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC, United Statesen_US
dc.description.affiliatesDivision of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, United Statesen_US
dc.description.affiliatesGerman Paediatric Pain Centre, Children's and Adolescent's Hospital, Datteln, Germanyen_US
dc.description.affiliatesChildren's Pain Therapy and Paediatric Palliative Care, Faculty of Health, School of Medicine, Witten/Herdecke University, Witten, Germanyen_US
dc.description.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/31335640/en_US
dc.type.studyortrialSystematic Reviewsen_US
dc.type.specialtyAnaesthesiaen_US
dc.type.specialtyPain Medicineen_US
dc.identifier.fulltextlinkhttps://journals.lww.com/pain/abstract/2019/08000/pharmacological_interventions_for_chronic_pain_in.5.aspxen_US
item.openairetypeJournal Article-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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