AIRR - ANZCA Institutional Research Repository
Skip navigation
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSkowno, J-
dc.contributor.authorKarpelowsky, Jonathan S-
dc.contributor.authorWatts, Nicola R-
dc.contributor.authorLittle, David G-
dc.identifier.citationPaediatric anaesthesia 2016-12; 26(12): 1188-1196-
dc.description.abstractVascular complications following pediatric liver transplantation occur in 8-10% of cases, and no continuous, non-invasive monitoring for this problem exists. Near infrared spectroscopy (NIRS) allows non-invasive, continuous, transcutaneous assessment of hemoglobin oxygenation (StO2) 1-4 cm below the skin surface. We hypothesized that transcutaneous NIRS would be able to detect severe hepatic ischemia, and tested this in an animal model using 15-20 kg and 5-7 kg juvenile pigs. Direct liver surface and transcutaneous hepatic tissue hemoglobin oxygen saturation (StO2) were measured during occlusions of the hepatic artery and portal vein. Changes in hepatic delivery of oxygen (HepDO2) were calculated for each ischemic challenge and compared to changes in direct liver surface (DirHepStO2) and transcutaneous liver StO2measurements (CutHepStO2). In the 15-20 kg animals during complete occlusion, CutHepStO2decreased by 6.0(±4.9)%, whilst DirHepStO2decreased by 83.7(±7.2)%. In the 5-7 kg animals during complete occlusion, CutHepStO2decreased by 27.4(±8.5)%, whilst DirHepStO2decreased by 82.8(±4.6)%. Transcutaneous hepatic StO2monitoring cannot reliably detect severe hepatic ischemia in a juvenile porcine model, although a stronger and potentially useful signal is seen in 5-7 kg pigs. Trials of this technology should be currently restricted to situations where the organ is less than 1 cm from the skin surface, corresponding to infants of <10 kg.-
dc.subject.meshDisease Models, Animal-
dc.subject.meshReproducibility of Results-
dc.subject.meshSpectroscopy, Near-Infrared-
dc.titleCan transcutaneous near infrared spectroscopy detect severe hepatic ischemia: a juvenile porcine model.-
dc.typeJournal Article-
dc.identifier.journaltitlePaediatric anaesthesia-
dc.contributor.anzcaSkowno, J-
Appears in Collections:Scholarly and Clinical

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.