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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/274
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dc.contributor.authorBellomo, R-
dc.contributor.authorCorcoran, T-
dc.contributor.authorForbes, A-
dc.contributor.authorWallace, S-
dc.contributor.authorPeyton, P-
dc.contributor.authorChristophi, C-
dc.contributor.authorStory, DA-
dc.contributor.authorLeslie, K-
dc.contributor.authorSerpell, J-
dc.contributor.authorMcGuinness, S-
dc.contributor.authorParke, R-
dc.date.accessioned2018-03-08T22:36:23Z-
dc.date.available2018-03-08T22:36:23Z-
dc.date.issued2017-
dc.identifier.citation7:e015358en_US
dc.identifier.issn2044-6055en_US
dc.identifier.urihttp://hdl.handle.net/11055/274-
dc.description.abstractIntroduction The optimal intravenous fluid regimen for patients undergoing major abdominal surgery is unclear. However, results from many small studies suggest a restrictive regimen may lead to better outcomes. A large, definitive clinical trial evaluating perioperative fluid replacement in major abdominal surgery, therefore, is required. Methods/analysis We designed a pragmatic, multicentre, randomised, controlled trial (the RELIEF trial). A total of 3000 patients were enrolled in this study and randomly allocated to a restrictive or liberal fluid regimen in a 1:1 ratio, stratified by centre and planned critical care admission. The expected fluid volumes in the first 24 hour from the start of surgery in restrictive and liberal groups were ≤3.0 L and ≥5.4 L, respectively. Patient enrolment is complete, and follow-up for the primary end point is ongoing. The primary outcome is disability-free survival at 1 year after surgery, with disability defined as a persistent (at least 6 months) reduction in functional status using the 12-item version of the World Health Organisation Disability Assessment Schedule. Ethics/dissemination The RELIEF trial has been approved by the responsible ethics committees of all participating sites. Participant recruitment began in March 2013 and was completed in August 2016, and 1-year follow-up will conclude in August 2017. Publication of the results of the RELIEF trial is anticipated in early 2018.en_US
dc.titleRestrictive versus liberal fluid therapy in major abdominal surgery (RELIEF): rationale and design for a multicentre randomised trialen_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleBMJ Openen_US
dc.identifier.doi10.1136/bmjopen-2016-015358en_US
dc.description.affiliatesAustralian and New Zealand College of Anaesthetistsen_US
dc.description.pubmedurihttp://bmjopen.bmj.com/content/7/3/e015358en_US
dc.type.studyortrialClinical Trialen_US
dc.identifier.studynameTrial registration number ClinicalTrials.gov identifier NCT01424150.en_US
dc.ispartof.anzcaresearchfoundationYes-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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