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Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/273
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dc.contributor.authorHiller, JM-
dc.contributor.authorParat, MD-
dc.contributor.authorBen-Eliyahu, S-
dc.date.accessioned2018-03-08T22:36:14Z-
dc.date.available2018-03-08T22:36:14Z-
dc.date.issued2015-
dc.identifier.citation5(3):291-304en_US
dc.identifier.urihttp://hdl.handle.net/11055/273-
dc.description.abstractThe perioperative period of cancer surgery and its impact on patients’ long-term cancer outcomes is of increasing research interest. The physiological changes coincident with surgery are characterized by a stress response manifesting as activation of inflammatory pathways and immunosuppression. These changes are potentially deleterious to a patient’s capacity to control residual or released tumor cells. Of particular relevance to anesthesiologists is the role of available adjuncts that may offset these changes to improve patients' recovery from surgery and their long-term cancer outcomes. Animal and human evidence indicates a potential therapeutic benefit for β-adrenergic receptor antagonists, selective cyclooxygenase inhibitors, and anti-fibrinolytics administered through the perioperative period. In addition to reducing the surgical stress response, these agents may effect the cancer-host tissue interface to reduce cancer invasion and dissemination. Future research will focus on defining the role of these agents as integral perioperative adjuncts for cancer surgery.en_US
dc.subjectcanceren_US
dc.subjectanti-inflammatoriesen_US
dc.subjectanit-fibrinoyticsen_US
dc.subjectCelecoxiben_US
dc.subjectPropranololen_US
dc.titleThe Role of Perioperative Pharmacological Adjuncts in Cancer Outcomes: Beta-Adrenergic Receptor Antagonists, NSAIDs and Anti-fibrinolyticsen_US
dc.typeJournal Articleen_US
dc.type.contentTexten_US
dc.identifier.journaltitleCurrent Anesthesiology Reportsen_US
dc.identifier.doi10.1007/s40140-015-0113-xen_US
dc.description.affiliatesAustralian and New Zealand College of Anaesthetistsen_US
dc.ispartof.anzcaresearchfoundationYesen_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
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