AIRR - ANZCA Institutional Research Repository
Skip navigation
Please use this identifier to cite or link to this item: https://hdl.handle.net/11055/264
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMerry, AF-
dc.contributor.authorHannam, Jacqueline A-
dc.contributor.authorWebster, Craig S-
dc.contributor.authorEdwards, Kylie-Ellen-
dc.contributor.authorTorrie, J-
dc.contributor.authorFrampton, Chris-
dc.contributor.authorWheeler, Daniel W-
dc.contributor.authorGupta, Arun K-
dc.contributor.authorMahajan, Ravi P-
dc.contributor.authorEvley, Rachel-
dc.contributor.authorWeller, JM-
dc.date.accessioned2018-03-08T22:25:02Z-
dc.date.available2018-03-08T22:25:02Z-
dc.date.issued2017-
dc.identifier.citationAnesthesiology 2017; 126(3): 472-481-
dc.identifier.urihttp://hdl.handle.net/11055/264-
dc.description.abstractSimulation has been used to investigate clinical questions in anesthesia, surgery, and related disciplines, but there are few data demonstrating that results apply to clinical settings. We asked "would results of a simulation-based study justify the same principal conclusions as those of a larger clinical study?" We compared results from a randomized controlled trial in a simulated environment involving 80 cases at three centers with those from a randomized controlled trial in a clinical environment involving 1,075 cases. In both studies, we compared conventional methods of anesthetic management with the use of a multimodal system (SAFERsleep; Safer Sleep LLC, Nashville, Tennessee) designed to reduce drug administration errors. Forty anesthesiologists each managed two simulated scenarios randomized to conventional methods or the new system. We compared the rate of error in drug administration or recording for the new system versus conventional methods in this simulated randomized controlled trial with that in the clinical randomized controlled trial (primary endpoint). Six experts were asked to indicate a clinically relevant effect size. In this simulated randomized controlled trial, mean (95% CI) rates of error per 100 administrations for the new system versus conventional groups were 6.0 (3.8 to 8.3) versus 11.6 (9.3 to 13.8; P = 0.001) compared with 9.1 (6.9 to 11.4) versus 11.6 (9.3 to 13.9) in the clinical randomized controlled trial (P = 0.045). A 10 to 30% change was considered clinically relevant. The mean (95% CI) difference in effect size was 27.0% (-7.6 to 61.6%). The results of our simulated randomized controlled trial justified the same primary conclusion as those of our larger clinical randomized controlled trial, but not a finding of equivalence in effect size.-
dc.language.isoeng-
dc.subject.meshAnesthesia-
dc.subject.meshAustralia-
dc.subject.meshMedication Errors-
dc.subject.meshNew Zealand-
dc.subject.meshProspective Studies-
dc.subject.meshReproducibility of Results-
dc.subject.meshSimulation Training-
dc.titleRetesting the Hypothesis of a Clinical Randomized Controlled Trial in a Simulation Environment to Validate Anesthesia Simulation in Error Research (the VASER Study).-
dc.typeJournal Article-
dc.typeMulticenter Study-
dc.typeRandomized Controlled Trial-
dc.typeValidation Studies-
dc.typeResearch Support, Non-U.S. Gov't-
dc.identifier.journaltitleAnesthesiology-
dc.identifier.doi10.1097/ALN.0000000000001514-
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/28079566-
dc.identifier.pubmedid28079566-
dc.ispartof.anzcaresearchfoundationYes-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairetypeMulticenter Study-
item.openairetypeRandomized Controlled Trial-
item.openairetypeValidation Studies-
item.openairetypeResearch Support, Non-U.S. Gov't-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scholarly and Clinical
Show simple item record

Page view(s)

18
checked on Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.